|
KMID : 0378019830260060112
|
|
New Medical Journal
1983 Volume.26 No. 6 p.112 ~ p.116
|
|
|
Therapeutic effect of the dopamine receptor agonist for the Parkinson Syndrome
|
|
|
|
|
Abstract
|
|
|
15 Patients with Parkinsonism, either with intractable symptoms despite optimum dosage levdopa therapy combined with dopa decarboxylase inhibitors and anticholinergics or with adverse effects from these antiparkinsonian agents limiting its usefulness, were treated with bromocriptine, a dopamine receptor agonist, with gradually increasing up to 22.5mg daily doses.
All were maintained previously used other antiparkinson agents. Duration of the bromocriptine therapy were, 4 months and observed in the Department of Neurology, Seoul Nation,´ University Hospital. Improvement was seen in 8 patients. They had at least a one-state decrease in disease severity after the scale of Hoehn and Yahr. Improvement occured in all categories of clinical symptoms and signs, but prominent improvement were seen in tremor and bradykinesia. As adverse effects of bromocriptine were seen in 2 patients visual hallucination, confusion, nausea, vomiting and postural hypotension. Bromocriptine is worth a trial as adjunctive drug in patients not doing well on levodopa therapy if other means to improve their conditions are not successful.
The related literature were briefly discussed.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|